Endothelial function in metabolic syndrome and its complications: the relationship of functional and structural changes in the cardiovascular system and mechanisms of vascular tone regulation

Abstract

Endothelial dysfunction is a systemic pathological disorder characterized by weakening of endothelium-dependent vasodilation and vascular remodeling, which is an early manifestation of pathological processes in the cardiovascular system. Vascular endothelial abnormalities in a clinical setting can be diagnosed by biochemical and functional markers. However, there is still no unified optimal method for diagnosing endothelial dysfunction. The aim of the project was to evaluate endothelial dysfunction in patients with metabolic syndrome and to improve the diagnosis and monitoring of treatment effectiveness. Endothelial dysfunction was studied using the method of wavelet analysis of skin temperature fluctuations, and a thermal test was used to assess the properties dynamic state of the endothelium. The obtained data were compared with endothelial dysfunction biochemical markers at baseline and in dynamics after the therapy. The study showed that the wavelet analysis of skin temperature fluctuations technique can be used for diagnosing the endothelial dysfunction. This technique is simple, convenient, reproducible, it has been confirmed by laboratory determination of endothelial dysfunction markers.