Neuroendocrine and pharmacological regulation of functions of phagocytic cells under experimental zymosan-induced peritonitis

Authors

  • Ju.I. Shilov Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State Medical University named after academician E.A. Wagner; Perm State National Research University
  • S.Ju. Shilov Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State Medical University named after academician E.A. Wagner
  • S.Ju. Barkov Perm State Medical University named after academician E.A. Wagner
  • Ya.A. Tulyaev Institute of Ecology and Genetics of Microorganisms UB RAS
  • V.P. Kotegov Perm State National Research University
  • T.A. Baeva Institute of Ecology and Genetics of Microorganisms UB RAS
  • N.A. Shilova Perm State Medical University named after academician E.A. Wagner

DOI:

https://doi.org/10.7242/2658-705X/2021.2.2

Keywords:

zymosan-induced peritonitis, inflammation, phagocytic cells, immune system, stress, adrenergic compounds, sex steroid hormones, dehydroepiandrosterone, sexual dimorphism of the immune system, new nonsteroidal anti-inflammatory drugs

Abstract

The effect of acute stress under conditions of pharmacological blockade of peripheral beta-adrenergic receptors by nadolol on the quantity of phagocytic cells, their uptake activity and acidification phagosomes, production of reactive oxygen species in zymosan peritonitis, immunomodulatory effect on the same parameters of dehydroepiandrosterone, the influence of castration on the sex dimorphism of inflammatory response of phagocytic cells, sex differences in stress changes in the inflammatory response and the effect of sex steroid hormones on them, immunomodulatory effect of a nonsteroidal anti-inflammatory drug based on (Z)-3-(2-oxo-2-(4-tolyl)-ethylidene) piperazine-2-one in comparison with diclofenac sodium on the function of phagocytic cells under the development of zymosan peritonitis were investigated in an experiments on non-inbred white rats of both sexes. The studies carried out open a number of new directions for elucidating the mechanisms of neuroendocrine regulation of the functions of phagocytic cells during inflammation, developing methodological approaches for the experimental preclinical assessment of new drugs using modern instrumental methods.

Supporting Agencies
Исследование выполнено при финансовой поддержке гранта РФФИ № 17 -44-590995-р_а «Нейроэндокринная и фармакологическая регуляция функций фагоцитирующих клеток при экспериментальном зимозановом перитоните» и Администрации Пермского края.

Author Biographies

  • Ju.I. Shilov, Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State Medical University named after academician E.A. Wagner; Perm State National Research University
    кандидат медицинских наук, доцент, старший научный сотрудник лаборатории экологической иммунологии,«ИЭГМ УрО РАН»; доцент кафедры иммунологии,ПГМУ им. академика Е.А. Вагнера; доцент кафедры микробиологии и иммунологии, ПГНИУ
  • S.Ju. Shilov, Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State Medical University named after academician E.A. Wagner
    кандидат медицинских наук, младший научный сотрудник лаборатории экологической иммунологии, «ИЭГМ УрО РАН»; доцент кафедры нормальной физиологии, ПГМУ им. академика Е.А. Вагнера
  • S.Ju. Barkov, Perm State Medical University named after academician E.A. Wagner
    старший лаборант кафедры иммунологии, ПГМУ им. академика Е.А. Вагнера
  • Ya.A. Tulyaev, Institute of Ecology and Genetics of Microorganisms UB RAS
    аспирант лаборатории экологической иммунологии
  • V.P. Kotegov, Perm State National Research University
    доктор медицинских наук, профессор кафедры фармакологии и фармации
  • T.A. Baeva, Institute of Ecology and Genetics of Microorganisms UB RAS
    кандидат биологических наук, научный сотрудник лаборатории биохимии развития микроорганизмов
  • N.A. Shilova, Perm State Medical University named after academician E.A. Wagner
    кандидат медицинских наук, доцент кафедры иммунологии

References

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Published

2021-07-01

Issue

No. 2 (2021)

Section

Research: theory and experiment

How to Cite

Shilov, J. ., Shilov, S. ., Barkov, S. ., Tulyaev, Y. ., Kotegov, V. ., Baeva, T. ., & Shilova, N. . (2021). Neuroendocrine and pharmacological regulation of functions of phagocytic cells under experimental zymosan-induced peritonitis. Perm Federal Research Centre Journal, 2, 15-26. https://doi.org/10.7242/2658-705X/2021.2.2