Mechanisms of hormonal control of thymic differentiation process in the aspect of pregnancy

Authors

  • S.V. Shirshev Institute of Ecology and Genetics of Microorganisms UB RAS
  • E.G. Orlova Institute of Ecology and Genetics of Microorganisms UB RAS
  • O.A. Loginova Institute of Ecology and Genetics of Microorganisms UB RAS
  • I.V. Nekrasova Institute of Ecology and Genetics of Microorganisms UB RAS
  • O.L. Gorbunova Institute of Ecology and Genetics of Microorganisms UB RAS

DOI:

https://doi.org/10.7242/2658-705X/2020.2.6

Keywords:

estriol, chorionic gonadotropin, leptin, ghrelin, kisspeptin, thymocytes, dendritic cells, subset of T lymphocytes (αβT cells, δT cells, Treg, Th17, iNKT), pregnancy

Abstract

The effect of hormones (chorionic gonadotropin, estriol, leptin, ghrelin, kisspeptin) in the regulation of cell differentiation in the thymus was studied, in concentrations being comparable with the content in peripheral blood during pregnancy. It was established that the studied hormones regulate the functional activity of myeloid and plasmacytoid thymic dendritic cells in different directions, thus mediating the regulatory effects on the differentiation of thymocytes in contact with them. Hormones modulate the expression of the co-stimulatory activation and inhibitory molecules on myeloid and plasmacytoid thymic dendritic cells, as well as the activity of the enzyme indolamine-2,3-dioxigenase in general, increasing the tolerogenic potential of thymus dendritic cells. Hormone-influenced myeloid and plasmocytoid dendritic cells of the thymus have opposite effects on the formation of natural regulatory subpopulations of thymocytes (iNKT, nTreg, Th17), contributing to the successful development of physiological pregnancy. The effects of the studied hormones on the differentiation of αβ and δT cells in the thymus are mediated by the influence of hormones on both types of thymus dendritic cells, which complements the understanding of the regulatory mechanisms of steroid-induced thymus involution during pregnancy. Thus, the hormones produced by the placenta during pregnancy regulate the maturation and functional activity of thymus dendritic cells, modulating their ability to influence the differentiation of regulatory and effector populations of thymocytes. The obtained results reveal new mechanisms of hormonal regulation of the thymic differentiation of cells of the immune system which can be realized at different periods of pregnancy.

Supporting Agencies
Работа выполнена при финансовой поддержке гранта РФФИ 16-44-590631-р «Гормональная регуляция тимического этапа дифференцировки лимфоцитов в аспекте беременности».

Author Biographies

  • S.V. Shirshev, Institute of Ecology and Genetics of Microorganisms UB RAS
    доктор медицинских наук, профессор, засуженный деятель науки РФ, заведующий лабораторией иммунорегуляции, Институт экологии и генетики микроорганизмов УрО РАН - филиал Пермского федерального исследовательского центра УрО РАН (ИЭГМ УрО РАН)
  • E.G. Orlova, Institute of Ecology and Genetics of Microorganisms UB RAS
    доктор биологических наук, ведущий научный сотрудник, ИЭГМ УрО РАН
  • O.A. Loginova, Institute of Ecology and Genetics of Microorganisms UB RAS
    кандидат биологических наук, инженер, ИЭГМ УрО РАН
  • I.V. Nekrasova, Institute of Ecology and Genetics of Microorganisms UB RAS
    кандидат биологических наук, научный сотрудник, ИЭГМ УрО РАН
  • O.L. Gorbunova, Institute of Ecology and Genetics of Microorganisms UB RAS
    кандидат биологических наук, научный сотрудник, ИЭГМ УрО РАН

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Published

2020-07-22

Issue

No. 2 (2020)

Section

Research: theory and experiment

How to Cite

Shirshev, S. ., Orlova, E. ., Loginova, O. ., Nekrasova, I. ., & Gorbunova, O. . (2020). Mechanisms of hormonal control of thymic differentiation process in the aspect of pregnancy. Perm Federal Research Centre Journal, 2, 58-65. https://doi.org/10.7242/2658-705X/2020.2.6