Mechanobiological study of the dynamics and morphology of cell structures by laser microscopy and applications in oncology

Authors

  • O.B. Naimark Institute of continuous media mechanics UB RAS
  • V.V. Grishko Institute of technical chemistry UB RAS
  • Y.V. Bayandin Institute of continuous media mechanics UB RAS
  • A.S. Nikityuk Institute of continuous media mechanics UB RAS

DOI:

https://doi.org/10.7242/2658-705X/2020.1.7

Keywords:

cell mechanobiology, coherent phase microscopy, open complexes, nonlinear dynamics, morphometry, mono and multifractality

Abstract

The research is devoted to experimental and theoretical substantiation of the use of mechanobiological characteristics of cells as phenotypic markers of oncological pathologies. In the development of approaches related to the study of the mechanical state of cells in the «normal» and in the evolution of tumors, a comparative analysis has been carried out of the nonlinear dynamics of cell structures on the basis of the original data on the dynamics of «phase thicknesses» of cells obtained by coherent phase microscopy. The results of experimental studies have been generalized on the basis of epigenetic models reflecting mechanobiological features of cell and tissue structures in the development of cancer.

Author Biographies

  • O.B. Naimark, Institute of continuous media mechanics UB RAS
    доктор физико-математических наук, профессор, заведующий лабораторией физических основ прочности, Институт механики сплошных сред УрО РАН - филиал Пермского федерального исследовательского центра УрО РАН (ИМСС УрО РАН)
  • V.V. Grishko, Institute of technical chemistry UB RAS
    кандидат химических наук, доцент, заведующий лабораторией биологически активных соединений, Институт технической химии УрО РАН - филиал Пермского федерального исследовательского центра УрО РАН (ИТХ УрО РАН)
  • Y.V. Bayandin, Institute of continuous media mechanics UB RAS
    кандидат физико-математических наук, старший научный сотрудник, ИМСС УрО РАН
  • A.S. Nikityuk, Institute of continuous media mechanics UB RAS
    младший научный сотрудник, ИМСС УрО РАН

References

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Published

2020-04-17

Issue

No. 1 (2020)

Section

Research: theory and experiment

How to Cite

Naimark, O. ., Grishko, V. ., Bayandin, Y. ., & Nikityuk, A. . (2020). Mechanobiological study of the dynamics and morphology of cell structures by laser microscopy and applications in oncology. Perm Federal Research Centre Journal, 1, 61-78. https://doi.org/10.7242/2658-705X/2020.1.7