Myelopeptides in the regulation of functional activity of macrophages under stress in vivo

Authors

  • T.V. Gavrilova Perm State Medical University named after E.A. Wagner
  • O.N. Gein Perm State Pharmateutical Academy
  • S.V. Gein Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State National Research University
  • M.V. Chereshneva Institute of Immunology and Physiology of the UB RAS
  • V.A. Chereshnev Institute of Immunology and Physiology of the UB RAS

DOI:

https://doi.org/10.7242/2658-705X/2020.1.6

Keywords:

myelopeptides, stress, macrophages, IL-1, IL-10

Abstract

«In vivo» effect of the myelopeptides MP-5 and MP-6 on the production of reactive oxygen species, the production of pro- and anti-inflammatory cytokines by peritoneal macrophages under normal conditions and under stress has been studied. «In vivo» effect of the myelopeptides MP-5 and MP-6 on macrophage apoptosis and the dynamics of corticosterone production under stress has been evaluated. It has been found out that the administration of myelopeptides to animals has a modulating effect on changes in the stress-induced production of reactive oxygen species, pro- and antiinflammatory cytokines. The introduction of MP-5 and MP-6 levels the inhibition of the microbicidal potential and production of IL-ф induced by immobilization stress. Myelopeptides did not influence apoptosis of peritoneal washout cells and corticosterone production under stress.

Author Biographies

  • T.V. Gavrilova, Perm State Medical University named after E.A. Wagner
    доктор медицинских наук, профессор, заведующая кафедрой офтальмологии, Пермский государственный медицинский университет им. академика Е.А. Вагнера (ПТМУ им. академика Е.А. Вагнера)
  • O.N. Gein, Perm State Pharmateutical Academy
    кандидат биологических наук, доцент, кафедра фармакологии, Пермская государственная фармацевтическая академия (ПГФА)
  • S.V. Gein, Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State National Research University
    доктор медицинских наук, профессор, зам. директора, Институт экологии и генетики микроорганизмов УрО РАН - филиал Пермского федерального исследовательского центра УрО РАН (ИЭГМ УрО РАН)
  • M.V. Chereshneva, Institute of Immunology and Physiology of the UB RAS
    доктор медицинских наук, профессор, главный научный сотрудник, Институт иммунологии и физиологии УрО РАН (ИИФ УрО РАН)
  • V.A. Chereshnev, Institute of Immunology and Physiology of the UB RAS
    доктор медицинских наук, профессор, академик РАН, главный научный сотрудник, ИИФ УрО РАН

References

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Published

2020-04-17

Issue

No. 1 (2020)

Section

Research: theory and experiment

How to Cite

Gavrilova, T. ., Gein, O. ., Gein, S. ., Chereshneva, M. ., & Chereshnev, V. . (2020). Myelopeptides in the regulation of functional activity of macrophages under stress in vivo. Perm Federal Research Centre Journal, 1, 53-60. https://doi.org/10.7242/2658-705X/2020.1.6