Immunomodulating effects of alpha-fetoprotein

Authors

  • V.A. Chereshnev Institute of Ecology and Genetics of Microorganisms UB RAS; Institute of Immunology and Physiology of the UB RAS
  • S.A. Zamorina Institute of Ecology and Genetics of Microorganisms UB RAS
  • V.P. Timganova Institute of Ecology and Genetics of Microorganisms UB RAS
  • M.S. Bochkova Institute of Ecology and Genetics of Microorganisms UB RAS
  • P.V. Khramtsov Institute of Ecology and Genetics of Microorganisms UB RAS
  • K. Yu. Shardina K Institute of Ecology and Genetics of Microorganisms UB RAS
  • M.B. Rayev Institute of Ecology and Genetics of Microorganisms UB RAS

DOI:

https://doi.org/10.7242/2658-705X/2020.1.4

Keywords:

alpha-fetoprotein, regulatory T-cells (Treg), interleukin-17-producing T-cells (Th17), immune memory T-cells, myeloid derived suppressor cells (MDSC), pregnancy

Abstract

Alpha-fetoprotein (AFP), synthesized by embryonic tissues, enters the bloodstream of a mother performing both transport and immunomodulating functions. The aim of the work is to assess the effect of AFP on the differentiation of regulatory (Treg and Th17) and effector (TEM, TEMRA) subpopulations in vitro. For this, isolated cultures of T-helper cells were incubated with physiological concentrations of the native AFP preparation (10, 50, 100 IU/ml). In our experimental model, no apparent effects of AFP on Treg/Th17 differentiation were revealed. However, it was found out that AFP impeded the conversion of naive helper T cells into TEM and TEMRA, while simultaneously reducing the total production of IL-4 and IFN-y cytokines by these cells. The next task is to study the role of AFP in the regulation of differentiation and functions of myeloid suppressor cells (MDSC). Understanding these processes will expand our vision of the role of AFP in the formation of fetomaternal tolerance, as well as to formulate a new concept of its action as a pharmacological drug.

Supporting Agencies
Статья подготовлена при финансовой поддержке грантов РФФИ № 16-44-590971 и № 19-415-590001. 38

Author Biographies

  • V.A. Chereshnev, Institute of Ecology and Genetics of Microorganisms UB RAS; Institute of Immunology and Physiology of the UB RAS
    академик РАН, доктор медицинских наук, ведущий научный сотрудник Лаборатории экологической иммунологии, Институт экологии и генетики микроорганизмов УрО РАН - филиал Пермского федерального исследовательского центра УрО РАН (ИЭГМ УрО РАН); профессор кафедры микробиологии и иммунологии биологического факультета, Пермский государственный национальный исследовательский университет (ПГНИУ)
  • S.A. Zamorina, Institute of Ecology and Genetics of Microorganisms UB RAS
    доктор биологических наук, профессор кафедры микробиологии и иммунологии биологического факультета (ПГНИУ); ведущий научный сотрудник лаборатории экологической иммунологии, ИЭГМ УрО РАН
  • V.P. Timganova, Institute of Ecology and Genetics of Microorganisms UB RAS
    кандидат биологических наук, младший научный сотрудник лаборатории экологической иммунологии, ИЭГМ УрО РАН
  • M.S. Bochkova, Institute of Ecology and Genetics of Microorganisms UB RAS
    кандидат биологических наук, научный сотрудник лаборатории экологической иммунологии, ИЭГМ УрО РАН
  • P.V. Khramtsov, Institute of Ecology and Genetics of Microorganisms UB RAS
    кандидат биологических наук, младший научный сотрудник лаборатории экологической иммунологии, ИЭГМ УрО РАН; ассистент кафедры микробиологии и иммунологии биологического факультета, ПГНИУ
  • K. Yu. Shardina K, Institute of Ecology and Genetics of Microorganisms UB RAS
    инженер, ИЭГМ УрО РАН
  • M.B. Rayev, Institute of Ecology and Genetics of Microorganisms UB RAS
    доктор биологических наук, ведущий научный сотрудник лаборатории экологической иммунологии, ИЭГМ УрО РАН; профессор кафедры микробиологии и иммунологии биологического факультета ПГНИУ

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Published

2020-04-17

Issue

No. 1 (2020)

Section

Research: theory and experiment

How to Cite

Chereshnev, V. ., Zamorina, S. ., Timganova, V. ., Bochkova, M. ., Khramtsov, P. ., Shardina K, K. Y., & Rayev, M. . (2020). Immunomodulating effects of alpha-fetoprotein. Perm Federal Research Centre Journal, 1, 38-44. https://doi.org/10.7242/2658-705X/2020.1.4