Prospects for the use of low-molecular-weight cationic peptide warnerin in dental practice

Authors

  • V.P. Korobov Institute of Ecology and Genetics of Microorganisms UB RAS
  • O.A. Shuliatnikova Perm State Medical University named after E.A. Wagner
  • L.M. Lemkina Institute of Ecology and Genetics of Microorganisms UB RAS
  • S.E. Porozova Perm National Research Polytechnic University
  • A.G. Rogozhnikov Perm State Medical University named after E.A. Wagner

DOI:

https://doi.org/10.7242/1998-2097/2018.3.6

Keywords:

defects of the maxillofacial region, microbial biofilms, low-molecular-weight cationic peptide warnerin

Abstract

The increase in the level of injuries, neoplasms and postoperative inflammatory complications of the maxillofacial region determines the relevance of the treatment of such patients. The violation of the anatomical integrity of the maxillofacial region changes the microbiocenosis of the oral cavity with the revitalization of biofilm formation processes on orthopedic structures. The article considers a solution to the problem of the formation of microbial film Staphylococcus epidermidis 33 on titanium dioxide in the nanomodification of its surface and the use of low-molecular-weight cationic peptide warnerin. This method has promising opportunities for the use in clinical dentistry to prevent and treat inflammatory postoperative complications among patients with acquired defects of the maxillofacial region and after dental implantation.

Supporting Agencies
Работа выполнена в рамках государственного задания; номер госрегистрации темы 01201353249 «Молекулярные механизмы адаптации микроорганизмов к факторам среды».

Author Biographies

  • V.P. Korobov, Institute of Ecology and Genetics of Microorganisms UB RAS
    кандидат медицинских наук, заведующий лабораторией биохимии развития микроорганизмов
  • O.A. Shuliatnikova, Perm State Medical University named after E.A. Wagner
    кандидат медицинских наук, доцент кафедры ортопедической стоматологии
  • L.M. Lemkina, Institute of Ecology and Genetics of Microorganisms UB RAS
    кандидат медицинских наук, старший научный сотрудник лаборатории биохимии развития микроорганизмов
  • S.E. Porozova, Perm National Research Polytechnic University
    доктор технических наук, профессор кафедры материалов, технологий и конструирования машин
  • A.G. Rogozhnikov, Perm State Medical University named after E.A. Wagner
    кандидат медицинских наук, доцент кафедры ортопедической стоматологии, ПГМУ

References

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Published

2018-11-02

Issue

No. 3 (2018)

Section

Research: theory and experiment

How to Cite

Korobov, V. ., Shuliatnikova, O. ., Lemkina, L. ., Porozova, S. ., & Rogozhnikov, A. . (2018). Prospects for the use of low-molecular-weight cationic peptide warnerin in dental practice. Perm Federal Research Centre Journal, 3, 58-63. https://doi.org/10.7242/1998-2097/2018.3.6