FEATURES OF THE FORMATION OF THE IMMUNE SYSTEM AMONG CHILDREN WITH CONGENITAL HEART DISEASE
DOI:
Keywords:
congenital heart disease, children, thymus, immune systemAbstract
The paper presents a comprehensive dynamic analysis of major components of the immune system among children with congenital heart disease (CHD) of varying degrees of difficulty with the use of modern immunological, immunochemical, histological, histochemical, cytochemical and electron microscopic research methods. It was found that children with CHD at birth have a significant functional immaturity of the primary organ of immunity – the thymus, especially the ones with complex heart defects. This fact is reflected on thymocyte proliferation and differentiation both in vivo and in vitro. In this regard, since birth blood of sick children contains a reduced level of naive T lymphocytes. After undergoing thymectomy for 3 years apoptosis of circulating lymphocytes (CD4+, CD8+) is growing, and the phagocytic properties of the innate immune cells are decreasing. The obtained results reflect the failure of the immune system among children with congenital heart defects.
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