HIV-INFECTION AND PROBLEMS OF ANTIRETROVIRAL THERAPY EFFECTIVENESS
DOI:
https://doi.org/10.7242/1998-2097/2018.1.2Keywords:
HIV-infection, pathogenesis, antiretroviral therapy, discordant responseAbstract
General data on HIV-infection pathogenesis are presented. Massive destruction of CD4+ T-lymphocytes in the intestine during the acute phase of the disease causes microbial translocation and immune system activation. With a chronic course of infection, persistent immune activation gradually depletes the CD4+ T-lymphocyte pool. Together with AIDS-associated diseases it leads to a fatal outcome against the backdrop of developing immunodeficiency. Efficiency criteria of antiretroviral therapy are also considered. Particular attention is paid to the phenomenon of discordant response to the treatment.
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