Pregnancy-associated proteins and their role in the regulation of t-immune memory cell differentation

Authors

  • S.A. Zamorina Institute of Ecology and Genetics of Microorganisms UB RAS
  • V.P. Timganova Institute of Ecology and Genetics of Microorganisms UB RAS
  • M.S. Bochkova Institute of Ecology and Genetics of Microorganisms UB RAS
  • L.S. Litvinova Immanuel Kant Baltic Federal University image/svg+xml
  • K.A. Yurova Immanuel Kant Baltic Federal University image/svg+xml
  • O.G. Khaziahmatova Immanuel Kant Baltic Federal University image/svg+xml
  • P.V. Khramtsov Institute of Ecology and Genetics of Microorganisms UB RAS; Immanuel Kant Baltic Federal University
  • S.V. Kochurova Institute of Ecology and Genetics of Microorganisms UB RAS
  • M.B. Rayev Institute of Ecology and Genetics of Microorganisms UB RAS

DOI:

https://doi.org/10.7242/2658-705X/2020.1.3

Keywords:

alpha-fetoprotein, chorionic gonadotropin, trophoblastic b-1-glycoprotein, T-cells of immune memory, pregnancy, CD45

Abstract

The role of chorionic gonadotropin (CG), alpha-fetoprotein (AFP) and pregnancy-specific β-1-glycoprotein (PSG) in the regulation of the processes determining the differentiation and maturation of naive T-cells into memory T-cells has been studied. It has been established that CG, AFP and PSG have a predominantly suppressing effect on the expression of CD28 and CD25 activation markers by naive T-cells (CD45RA+) and memory T-cells (CD45R0+), virtually without affecting the expression of CD71 proliferation marker. It has been established that the differentiation processes of naive T-cells and memory T-cells, under the influence of CG, AFP and PSG, are carried out with changing the expression of the - U2af1l4, Gfi1 and hTERT genes, which regulate the alternative splicing of the Ptprc gene (encoding CD45 molecule). At the same time, CG, AFP and PSG stimulated autocrine production of IL-2 with both naive and memory T-cells. Thus, for the first time, the modulating effects of the above-mentioned fetoplacental proteins in relation to the differentiation and functional activity of immune memory T-cells are shown.

Supporting Agencies
Работа выполнена при финансовой поддержке РФФИ, проект 16-44-590049, программы повышения конкурентоспособности (5-100) и субсидии «Организация проведения научных исследований 20.4986.2017/ВУ» БФУ им. И. Канта.

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Published

2020-04-17

Issue

No. 1 (2020)

Section

Research: theory and experiment

How to Cite

Zamorina, S. ., Timganova, V. ., Bochkova, M. ., Litvinova, L. ., Yurova, K. ., Khaziahmatova, O. ., Khramtsov, P. ., Kochurova, S. ., & Rayev, M. . (2020). Pregnancy-associated proteins and their role in the regulation of t-immune memory cell differentation. Perm Federal Research Centre Journal, 1, 31-37. https://doi.org/10.7242/2658-705X/2020.1.3