Соединения палладия - ингибиторы ферментов (обзор литературы)
DOI:
https://doi.org/10.7242/2658-705X/2021.4.1Ключевые слова:
абиогенез, генетический код, протобиомономеры, свойства аминокислот и нуклеотидных основанийАннотация
В настоящем обзоре собраны литературные данные 1969-2021 гг., направленные на изучение координационного окружения палладия в транс-координированных, бидентатных N, S, фосфиновых и иминофенольных комплексных соединениях металла, а также селективного воздействия палладия при ингибировании ферментативной активности и возможного проявления его токсичности. Показано, что соединения палладия ингибируют ферменты, участвующие в патогенезе ряда заболеваний, таких как болезнь Альцгеймера, Паркинсона, атеросклероз и сахарный диабет второго типа. Соединения палладия могут применяться в таргетной терапии рака не только по механизму воздействия на молекулу ДНК, но и в качестве ингибиторов опухолевых ферментов. Также известно, что соединения палладия могут использоваться в качестве ингибиторов ферментов вирусов ВИЧ-1, SARS-CoV-2, возбудителя сонной болезни, гнилостных бактерий и других микроорганизмов. В то же время некоторые комплексы палладия являются потенциальными токсинами и аллергенами из-за ингибирования ферментов, необходимых для нормального метаболизма. В данном обзоре обращено особое внимание на работы ученых Пермского федерального исследовательского центра УрО РАН, посвященные ингибированию моноаминоксидаз, участвующих в развитии болезни Паркинсона. Нами отмечено, что поиск новых комплексов палладия является перспективным направлением для биомедицины.
Библиографические ссылки
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